AlphaFold! Protein Folding, Beyond the Hype

with @vijaypande @smc90 We cover the news around Google DeepMind's AlphaFold system outperforming all others in the 14th biennial CASP challenge, which tracks progress, key metrics, and state-of-the-art on predictive techniques for 3-D protein folding. Structure is function in biology, and this is one of the grand challenges in biology. So is it really solved? Will it really revolutionize drug discovery? What's hype/ what's real when it comes to the buzz here; what are other applications; and what are the implications for open science, scientists, big companies, startups?