567: Early Onset Alzheimer's Investigated and Revealed in Colombia

It's an absolute honour to welcome author Jennie Erin Smith on the Colombia Calling podcast this week to discuss her latest book in which she investigates and chronicles her six-year investigation into the phenomenon of early onset Alzheimer's in rural Colombia. Jennie speaks to Emily Hart and Richard McColl. In the 1980s, a Colombian neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer’s disease. Over the next forty years of working with the “paisa mutation” kindred, he went on to build a world-class research program in a region beset by violence and poverty. In "Valley of Forgetting," Jennie Erin Smith brings readers into the clinic, the laboratories, and the Medellín trial center where Lopera’s patients receive an experimental drug to see if Alzheimer’s can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones’ brains to science and subjected themselves to invasive testing to help uncover how Alzheimer’s develops and whether it can be stopped. Buy the book! https://a.co/d/giumqZR  The Colombia Briefing is reported by Emily Hart: https://harte.substack.com/