#36: azithromycin (Zithromax) | A Macrolide For CAP SSTI, Strep, COPD, STDs, and Others

Azithromycin is a macrolide antibiotic used to treat many bacterial infections. Some common uses are for Community Acquired Pneumonia (CAP), Group A Strep, Acute Exacerbations of COPD, STDs, among other bacterial infections. One of the most commonly known dosing regimens is 500 mg on day one, then 250 mg on days 2-5. When using the reconstituted suspension it must be refrigerated once reconstituted it must be discarded after 10 days. Azithromycin works through the inhibition of RNA-dependent protein synthesis by binding to the 50S ribosomal subunit. By blocking transpeptidation this inhibits the chain elongation step of protein synthesis. Azithromycin distributes well into most tissues and fluids with the exception of cerebrospinal fluid (CSF). Protein binding is concentration dependent varying from 7-51%. Azithromycin can be taken with or without food but food may decrease any GI distress.  Go to DrugCardsDaily.com for my episode show notes which will contain a drug summary, quiz, and a link to FREE drug card sheets. SUBSCRIBE on Spotify or Apple Podcasts or search for us on your favorite place to listen to podcasts. I will go over the Top 100-200 Drugs as well as throwing in some recently released drugs that peak my interest. Also, if you’d like to say hello, suggest a drug, or leave any constructive feedback on the show I’d really appreciate it! Leave a voice message at anchor.fm/drugcardsdaily or message us through twitter @drugcardsdaily