Neuroendocrine breast tumors - a two-face disease?

Expert: Joana Ribeiro, Champalimaud Clinical Center, Lisbon, Portugal 1-Define breast cancer with NE differentiation and distinguish it from NEC 2-Discuss neuroendocrine differentiation as an independent adverse prognostic factor for shorter OS / DFS 3-Discuss Ki 67and differentiation between NET / NEC and OS / DFS 4-Discuss adjuvant treatment-  according to the same recommendations given for the other types of invasive breast cancer? 5-In the metastatic setting: types of chemotherapy in NEC and multimodality approach including specific therapies such as peptide receptor radionuclide therapy