The Inoculum Effect of Antibiotic Susceptibility Testing (JCM ed.)

The inoculum effect of antibiotic susceptibility testing is often discussed at playgrounds and infectious diseases conferences, but many of us don’t really have a clear definition of what it is or a good understanding of its importance. We’ll be talking about the inoculum effect and susceptibility testing of Staphylococcus aureus with cefazolin. Some of the questions we’ll discuss are: • What exactly is the inoculum effect and how is it measured? • Does the inoculum effect have clinical significance? • How common is the inoculum effect with Staph aureus and cefazolin?