Deep Dive MW R12

Introduction * Used as pesticides * Used as weapons (nerve agents) * Sarin Gas, VX Gas, Novichok * Transdermal, Inhalation, Ingestion Clinical Presentation * Muscarinic Activation (Dumbels Mnemonic) * Defication * Urination * Myosis * Bradycardia, Bronchospasm, and Bronchorrhea * “The Killer B’s” * Emesis * Lacrimation * Salivation and Sweating * Nicotinic Activation * Muscle weakness and paralysis * CNS Activation * Respiratory Depression * Altered Mental Status * Seizures Treatment * Atropine * Reverses Dumbels * Keep giving and doubling the dose until brochorrhea and bradycardia resolve * Pralidoxime * Only works before ‘aging’ occurs * Diazepam * Stops the seizures