418. Why "Calories In, Calories Out" Is Bullsh*t

Grow or Die Podcast - A podcast by Justin Mihaly

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In this eye-opening episode of the *Grow or Die* podcast, I take a deep dive into the oversimplified concept of "Calories In, Calories Out" (CICO). We explore why this approach to weight loss and metabolism is outdated, ineffective, and, in some cases, even harmful. I break down the science behind metabolism, dispelling common misconceptions and explaining how factors like basal metabolic rate, hormones, and nutrient absorption play critical roles in achieving and maintaining a healthy weight. You'll hear about real-world examples, like the contestants from The Biggest Loser and their struggles with weight regain, as well as the impact of severe caloric restriction on metabolism. We also cover the importance of understanding metabolic pathways, the role of polyunsaturated fatty acids, and how crash dieting can lead to long-term metabolic damage. Whether you're looking to optimize your health or curious about the science behind metabolism, this episode has the information you need to rethink how you approach weight loss.   Timestamps: - [00:28] – Sneak peek into the episode. - [1:41] – What is CICO, and why is it an oversimplification of human metabolism? - [2:41] – Why most people following CICO are unaware of metabolic dysfunctions. - [4:10] – How biofilms in the gut can impair nutrient absorption and affect metabolism. - [5:05] – The dangers of decreasing calories to unhealthy levels and how this impacts your metabolism long term. - [6:18] – The decline in metabolic rate over the last century and its contribution to rising obesity rates. - [8:09] – Explaining the second law of thermodynamics and why "a calorie is not a calorie" when it comes to metabolism. - [9:46] – The role of macronutrients in producing ATP and how different foods impact metabolism. - [11:54] – Debunking the idea that all fats and oils are created equal: Why polyunsaturated fatty acids may slow metabolism. - [14:07] – Lessons from historical diets and why past generations could eat more and maintain lower body weights. - [17:02] – The alarming rise in omega-6 intake and its negative effects on thyroid health and metabolism. - [20:36] – Why crash dieting leads to weight regain and long-term damage to basal metabolic rate. - [21:50] – How the body conserves energy during times of severe caloric restriction, and why this is counterproductive for weight loss. - [23:41] – The role of hormones in regulating metabolism, and how improper macronutrient ratios can harm thyroid health. - [27:16] – The benefits of prioritizing carbohydrates and lowering protein intake in certain health phases to boost metabolic function. - [31:00] – Why the majority of adults experience hypothyroidism and how modern blood tests miss the signs of metabolic dysfunction. - [35:12] – Actionable steps to improve metabolic health, including avoiding polyunsaturated fats, supporting liver function, and balancing hormones.   Links & Resources: Follow Me On Instagram: @jmihaly_ Follow "Grow or Die" On Instagram: @growordiepodcast Work With Me: https://www.togethermorefit.com/founder Join Substack For More Exclusive Content: https://justinmihaly.substack.com/ Join Patreon For More Exclusive Content: https://patreon.com/JustinMihaly?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Sign Up For The Together More Elite Mentorship: https://togethermorefit.com/elitepurchase   Sources: 1. PMID: 20613890   2. https://www.nature.com/articles/s42255-023-00782-2   3. https://fireinabottle.net/torpor-sloth-and-gluttony-scd1-causes-humans-to-store-fat/   4. PMID: 31908267   5. https://www.nature.com/articles/s42255-023-00782-2   6. PMID: 18137629   7. PMID: 20475077   8. https://fireinabottle.net/wp-content/uploads/2021/05/YearbookofAgriculture1939FoodAsLife-1.pdf   9. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00166-2   10. PMID: 30017356   11. PMID: 31430205   13. PMID: 18137629   14. PMID: 20475077   15. https://fireinabottle.net/wp-content/uploads/2021/05/YearbookofAgriculture1939FoodAsLife-1.pdf   16. Heckscher, Eli F., Sveriges ekonomiska historia från Gustav Vasa, Bonnier, Stockholm, 1935-1949   17. https://archive.org/details/economichistoryo0095unse/page/n10/mode/1up   18. PMID: 30484738   19. doi:10.1186/1475-2891-3-9   20. https://youtu.be/mif1GaSN13A?si=8povT619mM7TiCWj   21. https://doi.org/10.1186/1550-2783-1-2-21   22. https://www.jbc.org/article/S0021-9258(18)76564-2/pdf   23. https://in.nutrition.org/article/S0022-3166(23)12919-1/abstract   24. PMID: 6693988   25. https://www.jbc.org/article/S0021-9258(18)44892-2/pdf   26. http://raypeat.com/articles/articles/sugar-issues.shtml   27. https://www.sciencedirect.com/science/article/abs/pii/0304416586900164   28. PMID: 21367944   29. https://www.ers.usda.gov/data-products/chart-gallery/gallery/chart-detail/   31. PMID: 14962692   32. PMID: 31031634   33. https://www.researchgate.net/publication/236821460_The_Influence_of_Dietary_Fatty_Acids_on_Hibernation_by_Golden-Mantled_Ground_Squirrels_Spermophilus_lateralis   34. PMID: 26616007   35. https://jamanetwork.com/journals/jama/fullarticle/199765   36. https://onlinelibrary.wiley.com/doi/10.1111/j.0954-6820.1960.tb06642.x   37. https://www.nature.com/articles/0801270   38. PMID: 35721911   39. PMID: 22486171   40. https://jamanetwork.com/journals/jama/fullarticle/199765   41. https://www.ncbi.nlm.nih.gov/books/NBK500006/   42. https://www.sciencedirect.com/science/article/pii/S0014579314002701   43. https://care.diabetesjournals.org/content/24/12/2149   44. https://www.jbc.org/article/S0021-9258(18)94385-1/pdf   45. https://en.m.wikipedia.org/wiki/Cushing's_disease   46. https://www.sciencedirect.com/science/article/pii/S1550413117306150   47. https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.1963.tb00071.x   48. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2005-870240   49. PMID: 36237192   50. PMID: 7149777   51. https://www.kidney-international.org/article/S0085-2538(15)33538-9/pdf   52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970002/   53. https://www.nature.com/articles/0801270   54. PMID: 31430205   55. https://www.nytimes.com/2016/05/02/health/biggest-loser-weight-loss.html   56. PMID: 27136388   57. PMID: 26832439   58. https://youtu.be/MESSyNAIAag?si=c-h08QPhhiL72B5m   59. PMID: 9026527   60. https://doi.org/10.1016/bs.mcb.2022.05.003   61. https://doi.org/10.1016/j.freeradbiomed.2013.03.022   62. https://deniseminger.com/2015/10/06/in-defense-of-low-fat-a-call-for-some-evolution-of-thought-part-1/   63. PMID: 19531645   64. PMID: 16476868   65. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00166-2   66. PMID: 30017356   67. PMID: 20573247   68. https://www.universityofcalifornia.edu/news/fight-diseases-aging-scientist-makes-aging-itself-target   69. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.037137   70. https://www.npr.org/sections/health-shots/2016/06/13/481590997/millennials-may-be-losing-their-grip   71. https://academic.oup.com/inci/article/109/8/diw322/3053481   73. https://www.nih.gov/news-events/news-releases/rates-new-diagnosed-cases-type-1-type-2-diabetes-rise-among-children-teens   74. https://www.pnas.org/doi/10.1073/pnas.1718793115   75. https://www.sciencedirect.com/science/article/abs/pii/S0160289607000463   76. https://academic.oup.com/humupd/article/23/6/646/4035689