Dr Stefania Roberts & Dr Niamh Corduff - 'The Tox Talks (Chapter 3): Toxin resistance’ #176

Episode 176 hosts Dr Stephania Roberts (Phlebologist & Cosmetic Physician from Melbourne, Australia) & Dr Niamh Corduff (Plastic Surgeon from Geelong, Australia) In this mini series 'The Tox Talks', we feature expert injectors who have significant experience in using botulinum toxin. These episodes explore our guests experiences using particular brands, the evolution of their injecting techniques and we get special insights into the subtle nuances of getting the best our of toxins. In chapter 8 we discuss the poorly understood topic of toxin resistance. In what was one of our most engaging podcasts to date, our expert guests debated the topic and we covered: What we mean by ‘resistance’? Whether there's a difference between being resistant and being a ‘non-responder’?  What’s a primary non-responder vs secondary non-responder?  The incidence of toxin resistance - and the difficulty in quoting this rate  The main steps in how Botox (Allergan brand) is manufactured and why this is relevant to the topic How this differs from the manufacture of Xeomin (Merz brand) Accessory proteins and their role in the body's immune response Neutralising antibodies vs non-neutralising antibodies Does a higher dose create a higher risk of resistance If so, what do we mean by ‘high’ dose?   The role of dose frequency and risk of resistance    What steps an injector should go through to review a patient complaining that their toxin 'didn't work' How to explain a less than satisfactory toxin outcome to to a patient Should you swap your patient to a different brand of toxin if you don't see results? The phenomenon of post-lockdown 'failed' toxin treatments globally - was this real or just perceived? What tests can you do for a true primary non-responder and whether these are practical in an every day injectors clinic SUPPORT THE PODCAST: If you enjoy listening to IA every week and would like to help support the podcast in a small way, we have a simple donation option: Buy us a coffee PATREON: Did you know that we have an online injectable education and business mentoring service called IA Patreon? Get access to the following benefits: - Access to five main IA Whatsapp groups (General, Injectables, Skin & Devices, Business & Regenerative Aesthetics)  + three country specific groups (Australia, USA and UK) - Weekly IA Injectable Hints & Tips (Patient assessments, injecting videos & other injectable education) - NEW! Weekly Instagram Hints & Tips (Optimise your profile, content planning, how to use Instagram features, etc) - IA Business Hints & Tips (Videos of business hints and experiences) - IA Business Insights (Zoom recordings of David doing business coaching with our IA Patrons) - IA Zoom sessions (Bimonthly Zoom sessions focussing on injectable & business topics) - Access to our IA Library (Clinical papers, books & other resources) - Re-watch 8 x IA Webinars (Recorded in the pandemic with global experts) Our subscribers can also access: Business mentoring opportunities with David (additional cost, limited slots) Shadowing opportunities in clinic with Dr Jake (additional cost, limited slots)   CONTACT INFORMATION: Subscribe to IA on Apple Podcasts Subscribe to IA on Spotify   Other IA links: Follow IA on Instagram Sign up as an IA Patron Visit the IA website  Contact IA Apply to be a guest on IA Dr Jake Sloane: Follow Dr Jake on Instagram  Dr Jake's website David Segal: Follow David on Instagram