Development of Reference Materials for Noninvasive Prenatal Aneuploidy Testing by Massively Parallel Sequencing: A Proof-of-Concept Study

An original research article published in the July 2019 issue of the Journal of Applied Laboratory Medicine, describes a proof-of-concept study which tested the possibility of using artificial plasma matrix spiked with fragmented genomic DNA from immortalized cell lines to produce reference material for noninvasive prenatal testing assays.