TTR Cardiac Amyloid - How Common and How to Diagnose

TTR Cardiac Amyloid - How Common and How to Diagnose Guest: Omar F. Abou Ezzeddine, M.D., C.M., M.S. (@abouezzeddine) Host: Paul A. Friedman, M.D. (@drpaulfriedman) There are two main types of cardiac amyloidosis. One is a medical emergency involving light chain amyloid. The source of the amyloid is the bone marrow, which secretes excessive amounts of monoclonal protein that infiltrate the myocardium and cause an acute necrotic infiltrative and restrictive cardiomyopathy. In the second type, transthyretin (TTR) amyloidosis, the source of the protein is the liver. The course of TTR amyloidosis occurs over years. Joining us today to discuss cardiac amyloidosis is Omar F. Abou Ezzeddine, M.D., C.M., M.S., a consultant in Cardiovascular Medicine and director of the Cardiac Sarcoid Clinic at Mayo Clinic in Rochester, Minnesota. Specific topics discussed: Cardiac amyloidosis Signs and symptoms indicative of cardiac amyloidosis Patients who receive atrial fibrillation ablation and patients who receive transcatheter aortic valve replacement (TAVR) Tools for diagnosis, including pyrophosphate (PYP) and MRI scans Therapeutic options for patients with TTR amyloidosis, including tafamidis Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV. No CME credit offered for this episode. Podcast episode transcript found here.