S1 Episode 2: Antipsychotics in Schizophrenia: Effectiveness and Optimal Dosing

Drs John Kane and Stefan Leucht discuss the effectiveness and optimal dosing of antipsychotic medications in the treatment of schizophrenia. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969527). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Toward a Phenomenological Psychotherapy for Schizophrenia https://www.karger.com/Article/FullText/500163 APA Releases New Practice Guideline on Treatment of Patients with Schizophrenia https://www.psychiatry.org/newsroom/news-releases/apa-releases-new-practice-guideline-on-treatment-of-patients-with-schizophrenia Pharmacological Treatments for First-Episode Schizophrenia https://academic.oup.com/schizophreniabulletin/article/31/3/705/1894509?login=false Putting the Efficacy of Psychiatric and General Medicine Medication Into Perspective: Review of Meta-analyses https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/putting-the-efficacy-of-psychiatric-and-general-medicine-medication-into-perspective-review-of-metaanalyses/39C15F3428BDD1F8A4C152B67C06A5A6 The Nature of Relapse in Schizophrenia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599855 20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia https://pubmed.ncbi.nlm.nih.gov/29621900/ Amisulpride and Olanzapine Followed by Open-Label Treatment With Clozapine in First-Episode Schizophrenia and Schizophreniform Disorder (OPTiMiSE): A Three-Phase Switching Study https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(18)30252-9/fulltext Clozapine https://reference.medscape.com/drug/clozaril-versacloz-clozapine-342972 Lurasidone Dose Escalation in Early Nonresponding Patients With Schizophrenia: A Randomized, Placebo-Controlled Study https://www.psychiatrist.com/jcp/schizophrenia/lurasidone-in-early-nonresponding-schizophrenia/ Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19010034 Examination of Dosing of Antipsychotic Drugs for Relapse Prevention in Patients With Stable Schizophrenia: A Meta-analysis https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2783296 Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2725088