102: Potential of Gamma Sensory Stimulation in Alzheimer Disease

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, Brent Vaughan, chief executive officer of Cognito Therapeutics, provided insight on the mechanism of action behind the company's gamma sensory stimulation as a potential therapy for patients with Alzheimer disease. He spoke on the positive phase 2 OVERTURE study presented at the 2023 Clinical Trials on Alzheimer's Disease (CTAD) conference, including the notable takeaways from the trial and the safety profile observed. In addition, he commented on how this approach can be used with newer therapies and what the company is looking to achieve in a phase 3 trial. Looking for more Alzheimer disease/dementia discussion? Check out the NeurologyLive® Alzheimer disease/dementia clinical focus page. Episode Breakdown: 1:10 – Overview of phase 2 OVERTURE study 4:45 – Mechanism of action of gamma sensory stimulation  10:00 – Potential therapeutic crossover with emerging treatments 12:30 – Neurology News Minute 14:50 – Feasibility of the stimulation device 18:20– Future plans and planned phase 3 study This episode is brought to you by Medical World News, a streaming channel from MJH Life Sciences®. Check out new content and shows every day, only at medicalworldnews.com. The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: ATA188 Fails to Meet Primary End Point In Phase 2 EMBOLD Study of Progressive MS Elecsys Neurofilament Light Test Gains Breakthrough Device Designation as Way to Track MS Disease Activity FDA Clears Phase 2 Study of CAR T-Cell Therapy KYV-101 in Myasthenia Gravis Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.