DNA Papers #10: Harriet Ephrussi-Taylor and Rollin Hotchkiss

The tenth episode of the DNA papers podcast brings to light some of the lesser discussed papers in the history of DNA that were instrumental in confirming its role in effecting genetic transformation. Both papers discussed in this episode were first presented at the 1951 Cold Spring Harbor Symposium on Quantitative Biology; the first by a geneticist, and the second by a chemist, who were responsible for maintaining the continuity of work on bacterial transformation in Avery’s laboratory. These two papers provided important corroboration for the 1946 implication that the nucleic acid—DNA—of pneumococcus might be able to transform a variety of other bacterial traits besides their capsules and virulence. Ephrussi-Taylor, Harriett. “Genetic Aspects of Transformations of Pneumococci.” In Cold Spring Harbor Symposia on Quantitative Biology, 16:445–56. Cold Spring Harbor Laboratory Press, 1951. Hotchkiss, Rollin D. “Transfer of Penicillin Resistance in Pneumococci by the Desoxyribonucleate Derived from Resistant Cultures.” Cold Spring Harbor Symposia on Quantitative Biology 16 (January 1, 1951): 457–61. https://doi.org/10.1101/SQB.1951.016.01.032. Here to share their insights on these papers are: Eleonora Cresto, National Council for Scientific and Technical Research, Buenos Aires Geoffrey Montgomery, Independent Science Writer Michel Morange, IHPST, Université Paris I, Jan Witkowski, Cold Spring Harbor Laboratory Recorded on Sept 19, 2023. See also a collection of resources on this topic at https://www.chstm.org/video/144.