E37: Noor Siddiqui on embryo screening, the fertility crisis, and parenting

In this episode, Erik sits down with Noor Siddiqui, founder and CEO of Orchid. They discuss Orchid's recent breakthrough in embryo whole genome sequencing, the fertility crisis, parenting, dating, and more. -- RECOMMENDED PODCAST: History 102 with WhatifAltHist Every week, creator of WhatifAltHist Rudyard Lynch and Erik Torenberg cover a major topic in history in depth -- in under an hour. This season will cover classical Greece, early America, the Vikings, medieval Islam, ancient China, the fall of the Roman Empire, and more. Subscribe on Spotify: https://open.spotify.com/show/36Kqo3BMMUBGTDo1IEYihm Apple: https://podcasts.apple.com/us/podcast/history-102-with-whatifalthists-rudyard-lynch-and/id1730633913 YouTube: https://www.youtube.com/@History102-qg5oj -- We're hiring across the board at Turpentine and for Erik's personal team on other projects he's incubating. He's hiring a Chief of Staff, EA, Head of Special Projects, Investment Associate, and more. For a list of JDs, check out: eriktorenberg.com. -- RECOMMENDED PODCAST: Live Players with Samo Burja Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. Listen to Live Players: https://link.chtbl.com/liveplayers. -- SPONSOR: Head to Beehiiv, the newsletter platform built for growth, to power your own. Connect with premium brands, scale your audience, and deliver a beautiful UX that stands out in an inbox. 🐝to https://Beehiiv.com and use code "UPSTREAM" for 20% off your first three months. Shopify: https://shopify.com/torenberg for a $1/month trial period Shopify is the global commerce platform that helps you sell at every stage of your business. Shopify powers 10% of all ecommerce in the US. And Shopify's the global force behind Allbirds, Rothy's, and Brooklinen, and 1,000,000s of other entrepreneurs across 175 countries. From their all-in-one ecommerce platform, to their in-person POS system – wherever and whatever you're selling, Shopify's got you covered. With free Shopify Magic, sell more with less effort by whipping up captivating content that converts – from blog posts to product descriptions using AI. Sign up for $1/month trial period: https://shopify.com/torenberg. -- LINKS Orchid: https://www.orchidhealth.com/ -- X / TWITTER: @noor_siddiqui_ (Noor) @eriktorenberg (Erik) @upstream__pod @turpentinemedia -- TIMESTAMPS: (00:00) Preview (01:06) Intro (01:26) What is Orchid? (04:13) Genome sequencing for embryos: What Orchid has accomplished (07:00) The breakthrough that enabled Orchid's genome sequencing (08:32) The impact and significance of the polygenic risk score (11:59) What is IVF (15:19) Sponsors: Shopify (20:04) Concerns and stigmas around reproductive technology (26:10) On the Gattaca future where parents create perfect children (27:54) Moral panic around longevity (30:32) Anything that can improve things can be used in very hostile ways (33:30) What are the norms around having kids going to be 30-40 years from now (36:55) Noor's thoughts on declining fertility rates (42:13) Matchmaking and dating (48:21) Is the decline of men a real thing? (50:20) Increasing fertility rates, moving the culture, and the negative effects of fertility collapse (1:07:37) Trying out Orchid and how the test works (1:09:16) Wrap -- This show is produced by Turpentine: a network of podcasts, newsletters, and more, covering technology, business, and culture — all from the perspective of industry insiders and experts. We’re launching new shows every week, and we’re looking for industry-leading sponsors — if you think that might be you and your company, email us at [email protected]. Producer: Sam Kaufman Editor: Graham Bessellieu For guest or sponsorship inquiries please contact [email protected]