Isoniazid Toxicity in Dogs | VETgirl Veterinary Continuing Education Podcasts

In today's VETgirl online veterinary CE podcast, Dr. Justine Lee, DACVECC, DABT discusses isoniazid toxicosis in dogs. While isoniazid isn't a common toxicant seen in dogs, this antimicrobial (used to treat tuberculosis) can potentially be fatal when dogs get into poisonous amounts. Veterinary professionals must be aware of the narrow margin of safety with this human and veterinary antibiotic. Isoniazid poisoning in dogs (and rarely, cats) results in seizures, and is considered a potentially life-threatening neurotoxicant. The good news? Isoniazid has an antidote, Vitamin B6/pyridoxine, and prompt treatment and antidote therapy is necessary for best outcome.