#80 - Epigenetics of exercise adaptation and "muscle memory" with Dr Kevin Murach

Dr Glenn McConell chats with Assistant Professor Kevin Murach who is a rising star from the University of Arkansas, USA. Kevin is an expert on muscle, muscle growth, adaptation to exercise training, “muscle memory”, the regulation of muscle growth and muscle memory and the effect of aging etc. Muscle memory definitely seems real (especially in slow muscle fibers). Looks like epigenetics involved more than changes to muscle fibers nuclei. But more work needs to be done, especially in humans. We had a really great chat. I enjoyed it a lot. A very smart chap. Twitter: @KevinMurachPhD0:00. Introduction and welcome2:16. How Kevin got into exercise research6:53. What is “muscle memory”.9:15. Human evidence of muscle memory13:58. Mice models to investigate resistance training19:30. Training, detraining and retraining20:35. Comparing rodents and human re their different lifespans22:30. Evidence for muscle memory in mice after ex training31:05. Mouse model that has both endurance and strength effects33:25. Voluntary wheel running: matching the training35:45. 10% greater hypertrophy with retraining39:25. Mice slow postural muscles didn’t detrain!44:45. Mechanisms: epigenetics49:50. Muscle nuclei and exercise training/muscle memory1:02:00. Muscle memory and epigenetics in the nuclei1:05:40. MicroRNA and muscle memory1:07:30. Epigenetics1:08:35. Exercise training and each bout of exercise1:11:20. MicroRNA and muscle memory1:16:20. Balance of protein synthesis and breakdown1:20:20. Muscle memory: Endurance vs resistance training1:21:35. Time course of muscle memory1:23:55. How much training need to get muscle memory1:25:18. Specificity of ex training muscle memory1:26:40. Nature and nuture1:27:25. Dutch famine and epigenetics1:28:18. Age and muscle memory1:29:38. Biological sex and muscle memory1:30:40. Common misconceptions: use it or lose it1:31:38. Identical twins1:32:25. Don’t need to go hard or go home.1:33:05. Research experts vs influencers etc1:37:15. Takeaway messages1:39:44. Do health benefits have a memory too?1:41:45. Outro Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice