Joel Rurik: CAR-T Therapies to Reverse Cardiac Fibrosis

Injury to heart tissue results in non-functional scar tissue that compromises cardiac function. A new approach combines targeted lipid nanoparicles and mRNAs to reprogram immune cells to seek and destroy the pathogenic fibroblasts that limit heart function. Results from mice are promising, and indicate that these approaches may have significant value in treating a suite of human disorders.