Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

In this episode we discuss: Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial Whether being tolerant to stress is a sign of health Why it’s virtually impossible to apply hormesis in a practical sense The difference between reactive oxygen species production in a high energy state versus a low energy state   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/    Timestamps: 3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis 13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations 28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis   37:05 –the difference between producing ROS in a high energy state versus a low energy state 49:16 – the low energy, high ROS state is a feature of degenerative conditions